Comparative Genomics Research Program
R01
Clinical Trial Not Allowed
PAR-17-482
Open Date (Earliest Submission Date) January 5, 2018
National Human Genome Research Institute (NHGRI) invites applications for research developing comparative approaches that can be used to understand genome structure and function and the relationship between genomic features and phenotypes. This program supports studies that enable the use of a diverse array of species to advance our ability to understand basic biological processes related to human health and disease, as well as studies that develop novel analytical tools and resources for the comparative genomics research community.
Eligibility: Non-domestic (non-U.S.) Entities (Foreign Organizations)
Eligible Individuals (Program Director/Principal Investigator)
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support
Specific areas of research interest:
NHGRI is interested in supporting development of comparative genomics methods and resources with strong justification of biological relevance, particularly relevance to human health and disease, that will enable areas of research including, but not limited to:
- Genome structure and organization across multiple species, particularly in lineages with diverse or unusual genomic architectures
- The relationship between genomic structure and function, especially in non-coding regions of the genome
- Evolutionary patterns and processes across multiple species including but not limited to divergent and convergent patterns of gene modification, gene regulation (including splicing), regulatory element activity, and regulatory networks
- Better understanding of the relationship between changes in DNA sequence, transcriptomic and epigenomic signatures, and phenotype/fitness, given that they do not always have simple correlations;
- The genetic underpinnings and evolution of health-related function in multiple species;
- The comparative population genomics of highly variable regions in multiple species;
- Integration of the genomes from ancient DNA and extant species to elucidate the genetic bases and evolutionary forces underlying speciation, adaptation to diverse environments, and the connections among genes, environments, and phenotypic form and function.
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PAR-17-482.html |
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