MMV 11th Call for proposals, 2013
MMV welcomes projects in the hit-to-lead and lead optimization stages for new families of molecules specifically addressing the key priorities of the malaria eradication agenda: transmission blocking via the human host, and prevention of P. vivax relapse through killing of liver-stage hypnozoites or reactivating them so as to be killed in the blood stages.
In addition, proposals are sought for novel chemical series with a long half-life (ideally >10h in rodents) and confirmed in vivo efficacy that could have potential for well tolerated P. falciparum chemoprophylaxis or asexual blood stage treatment in humans. Any proposals based on existing chemotypes must clearly address known issues.
Please note that early target validation falls outside of our mandate.
Finally, we also welcome proposals on novel translational study concepts that enable early confirmation of relapse prevention, transmission blocking and prophylactic activity in humans.
There are two stages to the process of seeking funding of a project through the Medicines
for Malaria Venture. The first stage is a concise 3 page LOI outlining the project using the guidelines and
templates provided. These letters will be competitively assessed by MMV and MMV’s Expert
Scientific Advisory Committee (ESAC). A short‐list of projects will then be invited for the
submission of a more detailed proposal, which will be presented and discussed at the MMV
offices in Geneva, in a face‐to‐face meeting (later in 2013) with MMV and MMV ESAC.
Experience has shown that MMV funding is highly competitive and it is in your interest to
present all relevant data as completely and as concisely as possible.
Further instructions and the application template can be found at: http://www.mmv.org/
All applications using the specified template should be sent electronically to proposals@mmv.org by 12 noon CET March 15th, 2013.