W81XWH-17-R-BAA1 (Initial for Fiscal Year 2017)
FDA #: 12.420 [Military Medical Research and Development]
Key Dates
- Opening Date: October 1, 2016
- Revised Date: December 14, 2016
- Closing Date: September 30, 2017, 11:59 p.m. Eastern Time
Pre-Proposals/Pre-Applications: organizations are required to submit preliminary proposals/applications (pre-proposals/pre-applications) through Electronic Biomedical Research Application Portal (eBRAP).
The USAMRMC’s supporting acquisition office, the US Army Medical Research Acquisition Activity (USAMRAA), will be the awarding and administering office for proposals/applications selected for funding.
A. Research Areas of Interest
1. Military Infectious Diseases Research Program
The Military Infectious Diseases Research Program (MIDRP) focuses on vaccines, drugs, field-deployable clinical diagnostics and vector detection assays (human and vector), and novel therapeutics to treat multidrug-resistant organisms in combat wound infections, as well as vector control measures for insect vectors that transmit naturally occurring endemic diseases with demonstrated or potential capability to decrease military operational effectiveness. Diseases of principal interest to the MIDRP are malaria, dengue, diarrheal disease caused by bacteria, multidrug-resistant bacteria and fungi, and human immunodeficiency virus (HIV). The MIDRP also has smaller research programs focused on scrub typhus, adenovirus, and hemorrhagic fever viruses not found on the Defense Threat Reduction Agency (DTRA) biothreat list. The MIDRP does not support proposals/ applications for funding research on viral or bacterial biowarfare threats, chemical weapon threats, or cancer.
Research efforts that focus on novel technologies for the detection, prevention, and treatment of naturally occurring infectious diseases, such as norovirus and other viral diarrhea, Q fever (Coxiella burnetii), Crimean-Congo hemorrhagic fever, protozoal diarrhea, Rickettsiosis, Zika virus, Chikungunya virus, multidrug-resistant bacteria and fungi, as well as technologies that leverage current DoD intramural research efforts in malaria, dengue, bacterial diarrhea, and HIV are needed. MIDRP is interested in Investigational New Drug (IND)-enabling preclinical and clinical studies to facilitate the development of therapeutics for prevention or treatment of multidrug-resistant bacteria, fungi, and emerging infectious disease threats (e.g., Chikungunya virus, MERS-CoV, Zika virus).
The MIDRP is also interested in proposals/applications incorporating a systems biology approach. For more information, refer to Section V.E.2, Attachment 7, Data- and Research Resource-Sharing Plan.
Research Areas of Interest to the MIDRP are found in Appendix, Section I. Applicants are urged to read and consider these before preparing their applications.
Medical Biological Defense Research Program
The Defense Threat Reduction Agency (DTRA) Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) manages research directed towards medical biological defense. The DTRA JSTO-CBD has limited funding for proposals/applications submitted through the USAMRMC BAA. DTRA also seeks proposals/applications for its requirements through the Federal Business Opportunities (FedBizOpps) and the DoD Small Business Innovation Research (SBIR) Program solicitations. For information regarding DTRA business opportunities, visit the website at http://www.dtra.mil/Contracts/BusinessOpportunities.aspx.
The Medical Biological Defense Research Program (MBDRP) provides medical countermeasures for biological warfare agents. These countermeasures include specialized medical materiel or procedures designed to enhance protection. The priorities of the program are (a) prophylaxis or pretreatment to prevent any casualty; (b) identification and diagnosis of biological agents; and (c) treatment or supportive care regimens. The MBDRP is interested in proposals/applications and products incorporating a systems biology approach. For more information, refer to Section V.E.2, Attachment 7.
Examples of some of the infectious agents of interest are those causing anthrax, plague, and glanders; the Ebola, Marburg, Venezuelan, Western and Eastern equine encephalitis viruses; and poxvirus models of variola virus. Examples of toxins of interest include those from plants (Ricin) and bacteria (Staphylococcal enterotoxins, botulinum).
The Research Areas of Interest to the MBDRP are found in Appendix, Section V. Applicants are urged to read and consider these before preparing their applications.
Where to Obtain the Submission Package for Research Awards
To obtain the complete Grants.gov proposal/application package (hereinafter, submission package), including all required forms, perform a Grants.gov (http://www.grants.gov/) basic search using the Funding Opportunity Number W81XWH-17-R-BAA1.
Submission is a two-step process requiring both: (1) Pre-proposal/pre-application submission through eBRAP (https://eBRAP.org/); and (2) Full proposal/application submission through Grants.gov (http://www.grants.gov/).
Pre-Proposal/Pre-Application Submission and Content for Research Awards
Submission of a pre-proposal/pre-application is required and must be submitted through eBRAP (https://eBRAP.org/). If the USAMRMC is interested in receiving a full proposal/application, the PI will be sent an invitation via eBRAP to submit.
Because the invitation to submit a proposal/application is based on the contents of the pre-proposal/pre-application, a PI should not change the title or research objectives after the pre-proposal/pre-application is submitted. A PI and organization identified in the pre-proposal/pre-application should be the same as those intended for the full proposal/application submission. If any changes are necessary after submission of the pre-proposal/pre-application, the PI must contact the CDMRP Help Desk at help@eBRAP.org or 301-682-5507. A change in PI or organization after submission of the pre-proposal/pre-application will be allowed only at the discretion of the USAMRAA Contracting or Grants Officer.
The organization, Business Official, and PI must register in eBRAP before submitting a pre-proposal/pre-application. Upon completion of an organization’s registration in eBRAP and approval by the CDMRP Help Desk, the organization name will be displayed in eBRAP to assist the organization’s Business Officials and PIs as they register. The organization, Business Officials, and PIs must all be registered and affiliated in eBRAP.
Pre-proposals/pre-applications may be submitted at any time prior to the BAA closing date. Pre-proposals/pre-applications should describe specific ideas or projects that pertain to any of the areas described under “Program Description” in this BAA. A pre-proposal/pre-application must include a brief description of the scientific methods and design to address the problem as described below. Brochures or other descriptions of general organizational or individual capabilities will not be accepted as a pre-proposal/pre-application. DO NOT include any proprietary information in the pre-proposal/pre-application.
The pre-proposal/pre-application consists of the following components, which are organized in eBRAP by separate tabs. Refer to the General Submission Instructions, Section II.C., for additional information on pre-proposal/pre-application submission.
• Tab 1 – Application Information:
○ Enter the information as described in eBRAP before continuing the pre-proposal/ pre-application.
• Tab 2 – Application Contact:
○ Enter contact information for the PI. Enter the organization’s Business Official responsible for sponsored program administration (the “person to be contacted on matters involving this application” in Block 5 of the Grants.gov SF424 Form). The Business Official must either be selected from the eBRAP list or invited for the pre-proposal/pre-application to be submitted.
○ Select the performing organization (site at which the PI will perform the proposed work) and contracting organization (organization submitting on behalf of the PI, which corresponds to Block 5 on SF424), and click on “Add Organizations to this Pre-application.” The organization(s) must either be selected from the eBRAP drop-down list or invited for the pre-proposal/pre-application to be submitted.
○ It is recommended that PIs identify an Alternate Submitter in the event that assistance with pre-proposal/pre-application submission is needed.
NOTE: The eBRAP system does not require approval of the pre-proposal/pre-application by the PI’s organization.
• Tab 3 – Collaborators and Key Personnel:
○ To enable the USAMRMC to avoid COI during the screening and review processes, list the name, organization, and role of all scientific participants in the proposed research project, including co-investigators, mentors, collaborators, consultants, and subrecipients/subawardees.
• Tab 4 – Conflicts of Interest
○ List all individuals other than collaborators and key personnel who may have a COI in the review of the proposal/application (including those with whom the PI has a personal or professional relationship).
Federal agency personnel involved in the review process and/or with making funding recommendations are prohibited from being involved in the research proposed or assisting in any pre-proposal/pre-application, including, but not limited to, concept design, application development, budget preparation, and the development of any supporting documentation. If formal collaboration with Military Facility personnel is planned (i.e., included in the proposal/application in performance of the research), this prohibition is not applicable. However, these Military Facility personnel cannot be involved in the review process and/or with making funding recommendations.
Refer to the General Submission Instructions, Appendix 1, for additional information. For questions related to COI, contact the CDMRP Help Desk at help@eBRAP.org or 301-682-5507.
• Tab 5 – Required Files
NOTE: No figures, charts, graphs, or other additional material will be accepted during the pre-proposal/pre-application process.
Provide responses in the appropriate data fields for the following in eBRAP. DO NOT LEAVE ANY FIELDS BLANK. eBRAP will truncate characters exceeding the limit specified for each data field. Enter “none” if there is no information to be included.
○ Problem To Be Studied (4,000 character limit, including spaces).
○ Theoretical Rationale, Scientific Methods, and Design (4,000 character limit, including spaces).
○ Significance and/or Uniqueness of the Proposed Effort (4,000 character limit, including spaces).
○ Military Relevance and Impact (4,000 character limit, including spaces).
○ Brief Description of Research Involving Animals, Human Anatomical Substances and/or Human Subjects (4,000 character limit, including spaces).
Plans and Strategy for Translation, Implementation, and/or Commercialization (4,000 character limit, including spaces).
Upload document(s) as individual PDF files. eBRAP will not allow a document to be uploaded in the Required Files tab if the number of pages exceeds the limits specified below.
○ Budget Summary: Upload as “BudgetSummary.pdf.” Complete the two-page Budget Summary Form (available for download in eBRAP) as instructed.
○ PI and Key Personnel Biographical Sketches (five-page limit per individual): Use boldfaced type or highlight titles of publications relevant to the proposed project. All biosketches should be uploaded as a single combined file.
Refer to the General Submission Instructions, Section II.C., for detailed information.
• Tab 6 – Submit Pre-Application
This tab must be completed for the pre-proposal/ pre-application to be accepted and processed.
If you have any queries and if you are interested in applying for this research funding opportunity, please contact us at the Office of Research Services and we will be pleased to provide further information and support
e-mail: tropmed.mahidol.univ@gmail.com
A. Research Areas of Interest
1. Military Infectious Diseases Research Program
The Military Infectious Diseases Research Program (MIDRP) focuses on vaccines, drugs, field-deployable clinical diagnostics and vector detection assays (human and vector), and novel therapeutics to treat multidrug-resistant organisms in combat wound infections, as well as vector control measures for insect vectors that transmit naturally occurring endemic diseases with demonstrated or potential capability to decrease military operational effectiveness. Diseases of principal interest to the MIDRP are malaria, dengue, diarrheal disease caused by bacteria, multidrug-resistant bacteria and fungi, and human immunodeficiency virus (HIV). The MIDRP also has smaller research programs focused on scrub typhus, adenovirus, and hemorrhagic fever viruses not found on the Defense Threat Reduction Agency (DTRA) biothreat list. The MIDRP does not support proposals/ applications for funding research on viral or bacterial biowarfare threats, chemical weapon threats, or cancer.
Research efforts that focus on novel technologies for the detection, prevention, and treatment of naturally occurring infectious diseases, such as norovirus and other viral diarrhea, Q fever (Coxiella burnetii), Crimean-Congo hemorrhagic fever, protozoal diarrhea, Rickettsiosis, Zika virus, Chikungunya virus, multidrug-resistant bacteria and fungi, as well as technologies that leverage current DoD intramural research efforts in malaria, dengue, bacterial diarrhea, and HIV are needed. MIDRP is interested in Investigational New Drug (IND)-enabling preclinical and clinical studies to facilitate the development of therapeutics for prevention or treatment of multidrug-resistant bacteria, fungi, and emerging infectious disease threats (e.g., Chikungunya virus, MERS-CoV, Zika virus).
The MIDRP is also interested in proposals/applications incorporating a systems biology approach. For more information, refer to Section V.E.2, Attachment 7, Data- and Research Resource-Sharing Plan.
Research Areas of Interest to the MIDRP are found in Appendix, Section I. Applicants are urged to read and consider these before preparing their applications.
Medical Biological Defense Research Program
The Defense Threat Reduction Agency (DTRA) Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) manages research directed towards medical biological defense. The DTRA JSTO-CBD has limited funding for proposals/applications submitted through the USAMRMC BAA. DTRA also seeks proposals/applications for its requirements through the Federal Business Opportunities (FedBizOpps) and the DoD Small Business Innovation Research (SBIR) Program solicitations. For information regarding DTRA business opportunities, visit the website at http://www.dtra.mil/Contracts/BusinessOpportunities.aspx.
The Medical Biological Defense Research Program (MBDRP) provides medical countermeasures for biological warfare agents. These countermeasures include specialized medical materiel or procedures designed to enhance protection. The priorities of the program are (a) prophylaxis or pretreatment to prevent any casualty; (b) identification and diagnosis of biological agents; and (c) treatment or supportive care regimens. The MBDRP is interested in proposals/applications and products incorporating a systems biology approach. For more information, refer to Section V.E.2, Attachment 7.
Examples of some of the infectious agents of interest are those causing anthrax, plague, and glanders; the Ebola, Marburg, Venezuelan, Western and Eastern equine encephalitis viruses; and poxvirus models of variola virus. Examples of toxins of interest include those from plants (Ricin) and bacteria (Staphylococcal enterotoxins, botulinum).
The Research Areas of Interest to the MBDRP are found in Appendix, Section V. Applicants are urged to read and consider these before preparing their applications.
Where to Obtain the Submission Package for Research Awards
To obtain the complete Grants.gov proposal/application package (hereinafter, submission package), including all required forms, perform a Grants.gov (http://www.grants.gov/) basic search using the Funding Opportunity Number W81XWH-17-R-BAA1.
Submission is a two-step process requiring both: (1) Pre-proposal/pre-application submission through eBRAP (https://eBRAP.org/); and (2) Full proposal/application submission through Grants.gov (http://www.grants.gov/).
Pre-Proposal/Pre-Application Submission and Content for Research Awards
Submission of a pre-proposal/pre-application is required and must be submitted through eBRAP (https://eBRAP.org/). If the USAMRMC is interested in receiving a full proposal/application, the PI will be sent an invitation via eBRAP to submit.
Because the invitation to submit a proposal/application is based on the contents of the pre-proposal/pre-application, a PI should not change the title or research objectives after the pre-proposal/pre-application is submitted. A PI and organization identified in the pre-proposal/pre-application should be the same as those intended for the full proposal/application submission. If any changes are necessary after submission of the pre-proposal/pre-application, the PI must contact the CDMRP Help Desk at help@eBRAP.org or 301-682-5507. A change in PI or organization after submission of the pre-proposal/pre-application will be allowed only at the discretion of the USAMRAA Contracting or Grants Officer.
The organization, Business Official, and PI must register in eBRAP before submitting a pre-proposal/pre-application. Upon completion of an organization’s registration in eBRAP and approval by the CDMRP Help Desk, the organization name will be displayed in eBRAP to assist the organization’s Business Officials and PIs as they register. The organization, Business Officials, and PIs must all be registered and affiliated in eBRAP.
Pre-proposals/pre-applications may be submitted at any time prior to the BAA closing date. Pre-proposals/pre-applications should describe specific ideas or projects that pertain to any of the areas described under “Program Description” in this BAA. A pre-proposal/pre-application must include a brief description of the scientific methods and design to address the problem as described below. Brochures or other descriptions of general organizational or individual capabilities will not be accepted as a pre-proposal/pre-application. DO NOT include any proprietary information in the pre-proposal/pre-application.
The pre-proposal/pre-application consists of the following components, which are organized in eBRAP by separate tabs. Refer to the General Submission Instructions, Section II.C., for additional information on pre-proposal/pre-application submission.
• Tab 1 – Application Information:
○ Enter the information as described in eBRAP before continuing the pre-proposal/ pre-application.
• Tab 2 – Application Contact:
○ Enter contact information for the PI. Enter the organization’s Business Official responsible for sponsored program administration (the “person to be contacted on matters involving this application” in Block 5 of the Grants.gov SF424 Form). The Business Official must either be selected from the eBRAP list or invited for the pre-proposal/pre-application to be submitted.
○ Select the performing organization (site at which the PI will perform the proposed work) and contracting organization (organization submitting on behalf of the PI, which corresponds to Block 5 on SF424), and click on “Add Organizations to this Pre-application.” The organization(s) must either be selected from the eBRAP drop-down list or invited for the pre-proposal/pre-application to be submitted.
○ It is recommended that PIs identify an Alternate Submitter in the event that assistance with pre-proposal/pre-application submission is needed.
NOTE: The eBRAP system does not require approval of the pre-proposal/pre-application by the PI’s organization.
• Tab 3 – Collaborators and Key Personnel:
○ To enable the USAMRMC to avoid COI during the screening and review processes, list the name, organization, and role of all scientific participants in the proposed research project, including co-investigators, mentors, collaborators, consultants, and subrecipients/subawardees.
• Tab 4 – Conflicts of Interest
○ List all individuals other than collaborators and key personnel who may have a COI in the review of the proposal/application (including those with whom the PI has a personal or professional relationship).
Federal agency personnel involved in the review process and/or with making funding recommendations are prohibited from being involved in the research proposed or assisting in any pre-proposal/pre-application, including, but not limited to, concept design, application development, budget preparation, and the development of any supporting documentation. If formal collaboration with Military Facility personnel is planned (i.e., included in the proposal/application in performance of the research), this prohibition is not applicable. However, these Military Facility personnel cannot be involved in the review process and/or with making funding recommendations.
Refer to the General Submission Instructions, Appendix 1, for additional information. For questions related to COI, contact the CDMRP Help Desk at help@eBRAP.org or 301-682-5507.
• Tab 5 – Required Files
NOTE: No figures, charts, graphs, or other additional material will be accepted during the pre-proposal/pre-application process.
Provide responses in the appropriate data fields for the following in eBRAP. DO NOT LEAVE ANY FIELDS BLANK. eBRAP will truncate characters exceeding the limit specified for each data field. Enter “none” if there is no information to be included.
○ Problem To Be Studied (4,000 character limit, including spaces).
○ Theoretical Rationale, Scientific Methods, and Design (4,000 character limit, including spaces).
○ Significance and/or Uniqueness of the Proposed Effort (4,000 character limit, including spaces).
○ Military Relevance and Impact (4,000 character limit, including spaces).
○ Brief Description of Research Involving Animals, Human Anatomical Substances and/or Human Subjects (4,000 character limit, including spaces).
Plans and Strategy for Translation, Implementation, and/or Commercialization (4,000 character limit, including spaces).
Upload document(s) as individual PDF files. eBRAP will not allow a document to be uploaded in the Required Files tab if the number of pages exceeds the limits specified below.
○ Budget Summary: Upload as “BudgetSummary.pdf.” Complete the two-page Budget Summary Form (available for download in eBRAP) as instructed.
○ PI and Key Personnel Biographical Sketches (five-page limit per individual): Use boldfaced type or highlight titles of publications relevant to the proposed project. All biosketches should be uploaded as a single combined file.
Refer to the General Submission Instructions, Section II.C., for detailed information.
• Tab 6 – Submit Pre-Application
This tab must be completed for the pre-proposal/ pre-application to be accepted and processed.
If you have any queries and if you are interested in applying for this research funding opportunity, please contact us at the Office of Research Services and we will be pleased to provide further information and support
e-mail: tropmed.mahidol.univ@gmail.com
