Deadline: 30 October, 2014
Budget: USD 100,000
Project length: 12 months
Investigators and/or co-investigators from malaria endemic areas are highly encouraged to apply and their applications will be prioritized over applications from non-malaria endemic countries. This call for applications is to encourage animal model testing of the malaria box hit compounds and their derivatives in neglected infectious disease models, such as schistosomiasis, cryptosporidiosis, filariasis, tuberculosis, as well as other infections where there is co-morbidity in children with malaria.
These Challenge Grants will be prioritized based on scientific merit. They should propose in vivo (animal) studies on neglected infectious diseases that afflict children in malaria endemic countries. They will also consider applications that propose to study malaria in animal models with the malaria box compounds or new compound series with novel anti-malarial compounds. Please note that for malaria studies, in vivo studies that address transmission blocking and liver stage malaria will be prioritized over in vivo studies that address only the asexual blood stages of malaria.
Proposals are expected to be at the stage where initial leads are identified against neglected disease pathogens, such that they have in vitro data supporting the efficacy of the compound(s) against neglected diseases, that demonstrate lack of toxicity against mammalian cells, and have pharmacokinetic (PK) parameters compatible with efficacious exposure. Please note MMV has data on PK exposure after oral dosing of mice with majority of malaria box compounds. This information is being prepared for open access release in the near future. If that information would be helpful for your application, please write vanvoorhisw@mmv.org for release of that information for up to ten malaria box compounds.
The proposed project should facilitate further development of the compounds and develop proof-of-concept information, such that further funding can be obtained.
They anticipate funding up to 5 projects that could begin as early as December 2014, depending on completion of a contract. Funding is to last no more than a year.
Please see the attachments for further details about the 2 page application requirements, the application template, and to review the contract terms to ensure your eligibility and willingness to abide by the contract.
If you are interested in applying to this grant, or have any further questions, please contact Paul, Tim, or Glad at the Office of Research Services. Below are links to the call for application documents.
Call for Proposals document
Instructions to apply
Template for Submission
Draft Letter of Agreement
