Friday, March 13, 2015

Joint Health Research Call: MRC - TRF - NSTDA - Newton Fund

       

Objectives and scope

“NATIONAL STRATEGIC DISEASES OF THAILAND”

Thailand is presently in a period of epidemiological transition, reflected in key changes in the morbidity and mortality. Today, the major and rising causes of death among Thai citizens are non-communicable diseases. The number one cause of death is cancer. The prevalence rate of communicable (infectious) diseases, which used to be significant health problems have been declining, however drug-resistant and re-emerging infectious diseases are a growing challenge for disease control and prevention in Thailand. For further details please refer to the Thailand’s Health Profile prepared by Bureau of Policy and Strategy, Ministry of Public Healthopens in new window.
To tackle these important, evolving health priorities, key research funding partners in Thailand and the UK have worked together to support this new joint funding initiative, as part of the Newton Fund.
The MRC is working with NSTDA and TRF to support research within the remits of both Thai funders to tackle disease areas of critical importance to the Thai population.
The following areas have been identified by UK and Thai partners as highlight areas and eligible diseases for this call.
The research proposed must be specifically relevant to the Thai population. For example, this may include understanding the cause of disease or epidemiology in the Thai population, or development or implementation of interventions for resource-poor communities.
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Infectious Diseases (to be supported by the MRC and NSTDA)

  • Dengue:   basic research related to dengue vaccine development
  • Malaria:    research and development related to drug resistant parasites (in particular artemisinin), detection, diagnostic kits, etc.
  • Outbreak prediction systems using mathematical models and novel data management systems (IT): particularly to inform emerging infectious disease outbreaks
  • New solutions for important emerging infectious diseases (EIDs) of pandemic threats / endemic infectious diseases: basic research, diagnostic kits, etc.
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Cancer, particularly those outlined below which are major causes of death in Thailand (to be supported by the MRC and TRF)

  • Lung cancer: basic research to understand the disease mechanisms, and research and development related to biological markers for disease detection, monitoring and treatment
  • Cholangiocarcinoma: basic research on early diagnostic markers, and potential new more effective therapies
  • Oesophageal cancer: basic research related to disease development mechanism, and biological marker for treatment
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Research activities

The funders, MRC NSTDA and TRF, welcome proposals for research in these diseases across the spectrum of research activities, from basic discovery research, understanding the mechanisms of disease, novel detection and diagnosis to development of novel preventatives (vaccines) and therapeutics
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Funding available

Funding will be provided by a partnership consisting of:
  • The National Science Technology Development Agency (NSTDA)
  • Thailand Research Fund (TRF)
  • Medical Research Council
The Medical Research Council will lead administration of this call in the UK. Funding from the Medical Research Council has been secured through the Newton Fundopens in new window.
NSTDA, MRC and TRF have earmarked up to £2,889,000 for this call.

NSTDA area:

  • MRC – GBP 1million (in support to the successful UK applicants)
  • NSTDA – GBP 556k (THB 30 million) in support to the successful Thai applicants

TRF area:

  • MRC – GBP 1million (in support to the successful UK applicants)
  • TRF – GBP 333k (THB 18 million) in support to the successful Thai applicants
It is expected that this funding will support up to 4 joint projects at a level of up to GBP 389k per project for infectious diseases, and 3 joint projects at a level of up to GBP 444k per project for non-communicable diseases.
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The Newton Fund

The UK contribution will be channeled from the Newton Fund. The Newton Fund is an initiative intended to strengthen research and innovation partnerships between the UK and emerging knowledge economies. It was launched by the Chancellor in April 2014, and will deliver £375 million of funding over the course of five years.
The Fund forms part of the UK’s Official Development Assistance (ODA) commitment which is monitored by the Organisation for Economic Cooperation and Development (OECD). ODA funded activity focuses on outcomes that promote the long-term sustainable growth of countries on the OECD Development Assistance Committee list. Newton Fund countries represent a sub-set of this list. For more information please visit the MRC Newton Fund pageopens in new window.
The Newton Fund requires that the funding be awarded in a manner that fits with Official Development Assistance (ODA) guidelinesopens in new window. All applications under this call must therefore be compliant with these guidelines. 
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Assessment Process

To be funded, proposals must be internationally competitive and at a standard equivalent to that normally expected to be supported by each funding organisation.
Key assessment criteria for the submissions will be:
  • Significance and Impact of the research
  • Scientific Rationale: novelty, importance and timeliness of the research;
  • Design and Feasibility of the Project Plan
  • Partnership: including strength and clarity of collaborations and opportunities provided, quality of the project management structure proposed;
  • Quality and suitability of the research environment and of the facilities;
  • Value for money for Thai and UK science;
  • Ethical considerations and governance arrangements.
Applications received and comments from all peer-reviewers will be assessed by MRC and TRF and NSTDA Review Panels in September. 
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Decision making process

Researchers planning to submit to this scheme are asked to submit an Expression of Interest including the names of the leading UK and Thai investigators and a preliminary project title, by Friday 1 May. The deadline for full applications is Tuesday 2 June
Full applications must be submitted by UK PI’s to MRC via the Je-S application system by 4pm, Tuesday 2 June 2015.
Funding decisions will be made through a joint process. This will include:
  1. Joint Expression of Interest emailed to international@headoffice.mrc.ac.uk by Friday 1 May 
  2. Joint application from  the UK and Thai researchers by Tuesday 2 June via Je-S
  3. Joint panel meetings of academic experts for MRC, TRF and NSTDA 
  4. Joint peer review process including UK and Thai academic reviews (plus other international reviewers as appropriate);
  5. Joint panel meetings of academic experts for MRC, TRF and NSTDA
  6. Funds released
The panel’s decision shall be final and will not be open to appeal
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How to apply

UK applications will be submitted to and processed by MRC. Please see guidance (PDF, 331KB)for further information.
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Contacts

For further information, UK applicants should contact:
For further information, Thai applicants should contact:  

Saturday, March 7, 2015

Department of Defense Peer Reviewed Medical Research Program (PRMRP)

The Fiscal Year 2015 (FY15) Defense Appropriations Act provides $247.5 million to the Department of Defense Peer Reviewed Medical Research Program (PRMRP). The vision of the PRMRP is to improve the health and well-being of all military Service Members, Veterans, and beneficiaries. The PRMRP challenges the scientific and clinical communities to address one of the FY15 congressionally directed topic areas with original ideas that foster new directions in basic science and translational research; novel product development leading to improved therapeutic or diagnostic tools; synergistic, multidisciplinary research program; or clinical trials that address an immediate clinical need. 

As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency, Research, Development, and Acquisition (DHA RDA) Directorate manages and executes the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The executing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP). 

The PRMRP is providing the information in this pre-announcement to allow investigators time to plan and develop applications. FY15 PRMRP Program Announcements and General Application Instructions are anticipated to be posted on Grants.gov by late March or early April 2015. Pre-application and application deadlines will be available when the Program Announcements are released. This pre-announcement should not be construed as an obligation by the government. 

Congressionally Directed Topic Areas. The FY15 PRMRP will solicit research applications for the following 41 topics areas: 

  • Acupuncture
  • Acute Lung Injury
  • Advanced Prosthetics
  • Arthritis
  • Burn Pit Exposure
  • Cardiovascular Heart Disease
  • Chronic Migraine and Post-Traumatic Headaches
  • Congenital Heart Disease
  • Dengue
  • Diabetes
  • DNA Vaccine Technology for Postexposure Prophylaxis
  • Dystonia
  • Focal Segmental Glomerulosclerosis
  • Food Allergies
  • Fragile X Syndrome
  • Healthcare-acquired Infection Reduction
  • Hepatitis B
  • Hereditary Angioedema
  • Hydrocephalus
  • Inflammatory Bowel Disease
  • Integrative Medicine
  • Interstitial Cystitis
  • Lupus
  • Malaria
  • Metals Toxicology
  • Mitochondrial Disease
  • Nanomaterials for Bone Regeneration
  • Osteoarthritis
  • Pancreatitis
  • Pathogen-inactivated Dried Plasma
  • Polycystic Kidney Disease
  • Post-Traumatic Osteoarthritis
  • Psychotropic Medications
  • Pulmonary Fibrosis
  • Respiratory Health
  • Rheumatoid Arthritis
  • Scleroderma
  • Sleep Disorders
  • Tinnitus
  • Vascular Malformations
  • Women's Heart Disease

Military Relevance: Relevance to the healthcare needs of the military Service Members, Veterans, and beneficiaries is a key feature of each FY15 PRMRP award mechanism.

Award MechanismEligibilityKey Mechanism ElementsFunding
Clinical Trial AwardAssistant Professor level or above (or equivalent)
  • Supports the rapid implementation of clinical trials of novel interventions with the potential to have a significant impact on patient care in the topic area(s) of interest
  • Proposed projects may range from small proof-of-concept trials through large-scale, definitive trials
  • Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to the Food and Drug Administration before the PRMRP Grants.gov application submission deadline
  • Preproposal submission is required; application submission is by invitation only
  • Funding limit not defined; requested funding must be appropriate for the scope of work proposed
  • Maximum period of performance is 5 years 
Discovery AwardAll Investigators
  • Supports the exploration of a highly innovative new concept or untested theory
  • Not intended to support the logical progression of an already established line of questioning
  • Clinical trials will not be funded
  • Reviewers will be blinded to the identity of the PI, collaborators, and their organization(s)
  • Maximum of $200,000 for direct costs (plus indirect costs)
  • Maximum period of performance is 18 months 
Focused Program AwardFull Professor level or above (or equivalent)
  • Restricted to the topic areas of Acupuncture, Advanced Prosthetics, Burn Pit Exposure, Cardiovascular Heart Disease, Congenital Heart Disease, Focal Segmental Glomerulosclerosis, Healthcare-acquired Infection Reduction, Hepatitis B, Hydrocephalus, Integrative Medicine, Metals Toxicology, Mitochondrial Disease, Nanomaterials for Bone Regeneration, Osteoarthritis, Pathogen-inactivated Dried Plasma, Pulmonary Fibrosis, Psychotropic Medications, Respiratory Health, Sleep Disorders, Vascular Malformations, and Women's Heart Disease
  • Supports a synergistic, multidisciplinary research program of at least four distinct but complementary projects addressing an overarching goal in one of the topic areas listed directly above
  • Projects should work together to answer critical questions, resolve differing hypotheses, and translate laboratory findings to clinical applications 
  • Projects may range from exploratory/hypothesis-developing through small-scale clinical trials that together will address the overarching goal/question
  • Research team of highly qualified, multidisciplinary project leaders should be led by a Principal Investigator with demonstrated success in directing large, focused projects
  • Preproposal submission is required; application submission is by invitation only
  • Maximum of $10 million for total costs (includes direct and indirect costs)
  • Maximum period of performance is 5 years
Investigator-Initiated Research AwardAssistant Professor level or above (or equivalent)
  • Supports research that will make an original and important contribution to the field of research or patient care in the topic area(s) of interest
  • Partnering Principal Investigator (PI) Option available
  • Clinical trials will not be funded
  • Preproposal submission is required; application submission is by invitation only
  • Maximum of $1.2 million for direct costs (plus indirect costs)
  • Maximum of $1.5 million for direct costs (plus indirect costs) for applications including a Partnering PI Option
  • Maximum period of performance is 3 years 
Technology/ Therapeutic Development AwardAssistant Professor level or above (or equivalent)
  • Supports the development of diagnostics or therapies that have the potential to make a strong impact on patient care in the topic area(s) of interest
  • Product-oriented: device, drug, clinical guidelines
  • Clinical trials will not be funded
  • Preproposal submission is required; application submission is by invitation only
  • Maximum of $1.8 million for direct costs (plus indirect costs)
  • Maximum period of performance is 3 years 

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.  

Applications must be submitted through the federal government's single-entry portal, Grants.gov. Submission deadlines are not available until the Program Announcements are released. Requests for email notification of the Program Announcements release may be sent to help@eBRAP.org.  

For more information about the PRMRP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil). 

Point of Contact:

CDMRP Public Affairs 
301-619-9783 
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil

Thursday, March 5, 2015

Gates Foundation Opportunities

The Gates foundation and its Grand Challenges partners are now accepting applications for the following grant programs – for more information please visit the grant opportunities page at www.grandchallenges.org   

1.    Grand Challenges Explorations, an initiative to encourage innovative and unconventional global health and development solutions, is now accepting grant proposals for its latest application round.  Applicants can be at any experience level; in any discipline; and from any organization, including colleges and universities, government laboratories, research institutions, non-profit organizations and for profit companies.

Proposals are being accepted online until May 13, 2015 on the following topics: 

•    Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering
•    Explore New Ways to Measure Delivery and Use of Digital Financial Services Data
•    Surveillance Tools, Diagnostics and an Artificial Diet to Support New Approaches to Vector Control 
•    New Approaches for Addressing Outdoor/Residual Malaria Transmission
•    Reducing Pneumonia Fatalities Through Innovations that Improve Pneumonia Diagnosis & Referral of Malnourished Children
•    Enable Merchant Acceptance of Mobile Money Payments 

Initial grants will be US $100,000 each, and projects showing promise will have the opportunity to receive additional funding of up to US $1 million. Full descriptions of the new topics and application instructions are available at www.grandchallenges.org 

2.     Saving Lives at Birth: A Grand Challenge for Development has launched its fifth round for innovative prevention and treatment approaches for pregnant women and newborns in poor, hard-to-reach communities around the world. Saving Lives at Birth partners will fund transformative approaches that cut across three main domains: (i) science & technology, (ii) service delivery, and (iii) demand-side innovation. 

The application deadline is March 27, 2015. Details on how to apply for a grant can be found at http://response.notifications.gatesfoundation.org/t?ctl=4C60472:87620EC6E05FE559EB842AA0F63DC43F2B785AAF7A4109CC& 

3.    All Children Reading: A Grand Challenge for Development has launched two grant opportunities:

- As part of the Technology to Support Education in Crisis and Conflict Settings Ideation Challenge, it is seeking technology-supported approaches to provide basic education in one or more of the following situations: health crisis, natural disaster, and conflict zone. Proposed solutions should be usable within the first six months after the onset of the crisis or conflict and be usable within the context of a developing country.  

The application deadline is March 30, 2015.  Details on how to apply can be found at http://response.notifications.gatesfoundation.org/t?ctl=4C60473:87620EC6E05FE559EB842AA0F63DC43F2B785AAF7A4109CC& 

- The Tracking & Tracing Books Prize Competition is seeking innovations to track books destined for early-grade classrooms and learning centers in low-income countries and allow stakeholders, ranging from parents to Ministries of Education and donor agencies, to quickly and easily access tracking information. 

The application deadline is April 1, 2015. Details on how to apply for a grant can be found at http://response.notifications.gatesfoundation.org/t?ctl=4C60474:87620EC6E05FE559EB842AA0F63DC43F2B785AAF7A4109CC& 

4.    The Global Health Innovative Technology Fund (GHIT) as part of its new Grand Challenges Japan initiative has launched a Target Research Platform to fund bold ideas in drugs, vaccines, and diagnostics for a set of priority neglected infectious diseases. Applications must be from a partnership between Japanese and non-Japanese organizations.

The application deadline is March 13, 2015.  Additional Information can be found at http://response.notifications.gatesfoundation.org/t?ctl=4C60475:87620EC6E05FE559EB842AA0F63DC43F2B785AAF7A4109CC& 

We are looking forward to receiving innovative ideas from around the world and from all disciplines.  If you have a great idea, please apply.  If you know someone who may have a great idea, please forward them this information.  

Wednesday, March 4, 2015

Global Infectious Disease Research Training Program (GID) D43 & D71

Global Infectious Disease Research Training Program (GID)

Status: Open

Announcement(s)

Deadlines

  • Deadlines for D43 and D71 letters of intent: 

    30 days prior to the application due date

  • Upcoming deadlines for D43 and D71 applications:
    July 29, 2015; July 29, 2016

Eligibility

Eligibility: Global Infectious Disease Research Training Program (D43)

  • U.S. Institutions with a demonstrated collaboration with a researcher in low- and middle-income country (LMIC) institutions may apply.
  • Foreign institutions in LMICs may also apply.
  • Applicant institution must have robust and high-quality research ongoing in the area(s) proposed.

Eligibility: Planning Grant for Global Infectious Disease Research Training Program (D71)

  • Applicants may only be submitted by foreign institutions in LMICs, as defined by the World Bank Classification system
  • Foreign applicants should apply in collaboration with U.S. institutions and must name an individual in the proposed institution as the major collaborator.

Applicant institutions for both the full institutional grant and the planning grant may submit more than one application, provided that each application is scientifically distinct. 

Program Overview

The Global Infectious Disease (GID) program addresses research training needs related to infectious diseases that are predominantly endemic in or impact upon people living in developing countries. The training programs include a variety of research training options to match the needs of the developing country institution. The ultimate goal is to build a critical mass of researchers and support staff to conduct independent infectious disease research in developing country institutions. 

Training programs may include:

  • Long-term (master's or doctoral degree and other training that is six months or longer) training for the full range of skills necessary to support research and research administration with the understanding that the focus of thesis and training-related research will be in their country.
  • Medium-term (three- to up to six-months) training or mentoring, including specialized clinical, laboratory, research or administrative/business skills necessary to support research that is planned or ongoing.
  • Short-term (less than three months) training or mentoring that focuses on research methodology, laboratory skills necessary to support research ethics and compliance issues, program and grants administration and financial management, grant writing, preparation of scientific manuscripts, data management, informatics, and other relevant areas. 
  • Institutional capacity-building efforts such as in-country training workshops in advanced research techniques, distance learning and informatics. 
  • Advanced in-country mentored research undertaken by the trainee in his/her home country upon completion of his/her initial period of long-term training under the program. 

Recent Awards

View a full list of GID Awards, including links to project information in NIH RePORTER.

Inquiries

Programmatic Issues

Barbara Sina, Ph.D.
Program Director
Division of International Training and Research
Fogarty International Center
National Institutes of Health
Building 31, Room B2C39
31 Center Drive, MSC 2220
Bethesda, MD 20892-2220
Telephone: (301) 402-9467
FAX: (301) 402-0779
Email: barbara_sina@nih.gov

Grants Management

Satabdi Raychowdhury
Grants Management Specialist
Fogarty International Center
Building 31, Room B2C29
31 Center Drive, MSC 2220
Bethesda, MD 20892-2220
Telephone: 301-496-9750
Fax: 301-594-1211
Email: Satabdi.Raychowdhury@nih.gov